I compiled the spectacular Waifu2x for macOS. I built it on macOS 12.0.1 using the latest available xcode. This particular build is for both x64 and Apple Silicon systems. The original github page can be found below.
https://github.com/imxieyi/waifu2x-mac
You can download the prebuilt application form my google drive.
Download Waifu2x form google drive